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Sunday, May 3, 2020 | History

4 edition of Airway smooth muscle found in the catalog.

Airway smooth muscle

modulation of receptors and response

by

  • 84 Want to read
  • 35 Currently reading

Published by CRC Press in Boca Raton .
Written in English

    Subjects:
  • Respiratory muscles -- Physiology.,
  • Smooth muscle -- Physiology.,
  • Airway (Medicine) -- Physiology.,
  • Muscle, Smooth -- physiology.,
  • Receptors, Endogenous Substances -- physiology.,
  • Respiratory Airflow -- physiology.,
  • Respiratory Muscles -- physiology.

  • Edition Notes

    Statementeditors, Devendra K. Agrawal, Robert G. Townley.
    ContributionsAgrawal, Devendra K., Townley, Robert G.
    Classifications
    LC ClassificationsQP121 .A574 1990
    The Physical Object
    Pagination303 p. :
    Number of Pages303
    ID Numbers
    Open LibraryOL1850355M
    ISBN 10084935904X
    LC Control Number90001825

    Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease. Tonio Pera and Raymond B. Penn. Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma. Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash. The book contains state-of-the-artconcepts ofplasma membrane receptors, smooth muscle contraction, activation of contractile proteins, and neural signals to theairways. Of particular value are chapters that deal with asthmatic hyperreactivity in allergic and exercise-inducedbronchoconstric­ tion. Airway smooth muscle cells. Here we provide the code which was used to contruct the RangedSummarizedExperiment object of the airway experiment data package. The experiment citation is: Himes BE, Jiang X, Wagner P, Hu R, Wang Q, Klanderman B, Whitaker RM, Duan Q, Lasky-Su J, Nikolos C, Jester W, Johnson M, Panettieri R Jr, Tantisira KG, Weiss ST, Lu Q. “RNA-Seq .


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Airway smooth muscle Download PDF EPUB FB2

Airway Smooth Muscle in Asthma and COPD is the first book of its kind that focuses entirely on the airway smooth muscle as the prime abnormality in airways diseases such as asthma.

Airways diseases are significant cause of morbidity and mortality across the world, and increasing research into these diseases has developed the understanding of pathophysiological processes in airways disease Format: Hardcover.

Airway smooth muscle plays an important role in the control of airway diameter, particularly in disease states such as asthma.

The patch-clamp technique and fluorescent ion-sensing dyes permit examination of ion channels along with changes in intracellular ion concentration in airway and other smooth muscles with better time resolution. In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle.

The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. In asthma and chronic obstructive pulmonary disease (COPD), bronchoconstriction evoked by smooth muscle shortening promotes airway obstruction, a hallmark of asthma and COPD.

Because increases in cytosolic calcium directly regulate the initiation and the development of ASM contraction, changes in calcium homeostasis may promote Airway smooth muscle book. Smooth muscle (so-named because the cells do not have striations) is present in the walls of hollow organs like the urinary bladder, uterus, stomach, intestines, and in the walls of passageways, such as the arteries and veins of the circulatory system, and the tracts of the respiratory, urinary, and reproductive systems (ab).Smooth muscle is also present in the eyes, where it functions to.

In-Situ Proliferation of Airway Smooth Muscle Cells Is Not Related to Cell Size or Number in Asthma John Elliot, Su-Ann Drew, Thais Mauad, Michael Abramson. Bitter taste receptor (TAS2R) expression on airway smooth muscle. Using quantitative RT-PCR, we utilized primers for all 25 human TAS2R receptors with mRNA from a purified cell preparation of cultured, early passage, human airway smooth muscle cells (HASM) [] to ascertain relative expression results are shown in Figure 1a, and are normalized to expression of the β 2 AR (ADRB2 Cited by: I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease.

After a period when it seemed that progress was very slow, there has been Airway smooth muscle book the past few years an incredibly rapid gathering ofBrand: Springer US.

This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum : Hardcover.

Airway smooth muscle (ASM) cells have been shown to play an important role in bronchial asthma. As the research progresses, the mechanism becomes more and more complex.

This chapter reviews the role of ASM in asthma pathological mechanisms including inflammatory reaction, extracellular matrix proteins, cell contraction, cell structure, neuromodulation, airway remodeling, apoptosis, autophagy Author: Wenchao Tang.

Although airway smooth muscle (ASM) has been implicated in constrictor hyperresponsiveness in asthma for decades, other important roles of ASM have recently been identified. Through Airway smooth muscle book airway relaxation and mediation of structural changes and inflammatory signaling, the ASM cell plays multiple diverse roles in the pathophysiology of by: Overexpression of ORMDL3 to Upregulate SERCA2b Correlates with Increased Airway Contractility and Ca2+ Oscillations in Airway Smooth Muscle in Precision-Cut Lung Slices Jun Chen, Marina Miller, Peter Rosenthal, David Broide, and Michael J.

Sanderson. The book contains state-of-the-art concepts of plasma membrane receptors, smooth muscle contraction, activation of contractile proteins, and neural signals to the airways.

Of particular value are the chapters that deal with asthmatic hyperreactivity in allergic and exercise-induced : Anthony S.

Rebuck. ISBN: OCLC Number: Description: xvi, pages: illustrations ; 24 cm: Contents: 1 Structure of Airway Smooth Muscle and Its. I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease.

After a period when it seemed that progress was very slow, there has been in the past few years an incredibly rapid gathering of knowledge in this area. Get this from a library. Airway Smooth Muscle in Health and Disease.

[Ronald F Coburn] -- I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease.

After a period when it seemed. Book Description. Airway smooth muscle plays a dominant role in bronchial asthma, as well as a significant role in various pulmonary diseases, such as chronic bronchitis, cystic fibrosis and emphysema.

Myogenic, neurogenic, and humoral factors control airway smooth-muscle tone. This text provides a state-of-the-art summary and critical. How to Cite. Sukkar, M. and Chung, K. () The Airway Smooth Muscle in Chronic Obstructive Pulmonary Disease (COPD), in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K.

Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: /ch Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the terminal bronchioles.

In utero, spontaneous phasic contraction of fetal ASM is critical for normal lung development by regulating intraluminal fluid movement, ASM differentiation, and release of key growth by: 1. A link between airway smooth muscle (ASM) and airway hyperresponsiveness (AHR) in asthma was first postulated in the midnineteenth century, and the suspected link has garnered ever increasing interest over the years.

AHR is characterized by excessive narrowing of airways in response to nonspecific stimuli, and it is the ASM that drives this by: 4. Calcium signaling plays an important role in cellular responses in almost all types of cells including airway smooth muscle cells.

This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. Airway smooth muscle by Devendra K. Agrawal, Robert G.

Townley, OctoCRC edition, Hardcover in EnglishCited by: Airway smooth muscle plays a dominant role in bronchial asthma, as well as a significant role in various pulmonary diseases, such as chronic bronchitis, cystic fibrosis and emphysema.

Myogenic, neurogenic, and humoral factors control airway smooth-muscle tone. This text provides a state-of-the-art s. This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells.

This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. Airway remodeling, a collective term for the structural changes of the asthmatic airway, can be characterized by increased airway smooth muscle (ASM) mass, goblet cell hyperplasia and.

In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified.

Aimed at specialists in pulmonology, this volume provides the Author: Kian Fan Chung. The active effector of airway reactivity is airway smooth muscle (ASM). The contractile status of airway smooth muscle is under the control of many extracellular messengers acting on specific. Smooth muscle is an involuntary non-striated is divided into two subgroups; the single-unit (unitary) and multiunit smooth muscle.

Within single-unit cells, the whole bundle or sheet contracts as a syncytium. Smooth muscle cells are found in the walls of hollow organs, including the stomach, intestines, urinary bladder and uterus, and in the walls of passageways, such as the FMA: The respiratory tract is covered in epithelium, which varies down the are glands and mucus produced by goblet cells in parts, as well as smooth muscle, elastin or of the epithelium (from the nose to the bronchi) is covered in ciliated pseudostratified columnar epithelium, commonly called respiratory epithelium.

The cilia beat in one direction, moving mucus towards FMA: In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified.

inhibitory effects on airway smooth muscle cause bronchodilation and may be mediated by the neurotransmitter 1._____ or by 2._____.

vasoactive intestinal peptide (VIP) 2. There are numerous smooth-muscle growth factors present in the asthmatic airway. Indeed, in culture, serum or bronchoalveolar-lavage fluid from patients with asthma causes greater proliferation of Cited by: Airway Smooth Muscle: Is There a Phenotype Associated with Asthma.

By Gautam Damera and Reynold A. Panettieri, Jr. Submitted: January 27th Reviewed: August 22nd Published: February 29th DOI: /Cited by: 1. Phenotypes of lung smooth muscle cells in health and disease are poorly characterized.

This is due, in part, to a lack of methodologies that allow for the independent and direct isolation of bronchial smooth muscle cells (BSMCs) and vascular smooth muscle cells (VSMCs) from the lung.

In this paper, we describe the development of a bi-fluorescent mouse that permits purification of these two. Figure 1: Autonomic (parasympathetic) innervation of the airways. Contrary to what some textbooks will tell you, there is no sympathetic innervation of airway smooth muscle.

The parasympathetic innervation of airway smooth muscle consists of cholinergic excitatory nerve fibres (releasing acetylcholine (ACh)) and so-called NANC inhibitory fibres (releasing mainly NO).

The primary functional abnormality in asthma is airway hyperresponsiveness (AHR)—excessive airway narrowing to bronchoconstrictor stimuli. Our understanding of the underlying mechanism(s) producing AHR is incomplete. While structure-function relationships have been evoked to explain AHR (e.g., increased airway smooth muscle (ASM) mass in asthma) more recently there has been a focus on Cited by: ASM - Airway Smooth Muscle.

Looking for abbreviations of ASM. It is Airway Smooth Muscle. Amazing Spider-Man (comic book) ASM: Automatic Storage Management (software) ASM: American Samoa (ISO Country code) ASM: Airway Smooth Muscle; airway stent; airway stent; airway stent; Airway Stent Customisation Protocol.

Calcium, a multitasking signaling actor in airway smooth muscle cells, as a target of novel strategies to limit airway disease. Stephane Tanguy*University Joseph Fourier-Grenoble 1, CNRS, TIMC-IMAG Laboratory CNRS UMR ,PRETA team, Grenoble, F, France *correspondence: @ book review on:Calcium Signaling In Airway Smooth Muscle Author: Stephane Tanguy.

To investigate the phenomenon of Ca(2+) sensitization, we developed a new intact airway and arteriole smooth muscle cell (SMC) "model" by treating murine lung slices with ryanodine-receptor antagonist, ryanodine (50 microM), and caffeine (20 mM).

A sustained elevation in intracellular Ca(2+) concentration ([Ca(2+)](i)) was induced in both SMC types by the ryanodine-caffeine treatment due to Cited by: Airway Smooth Muscle Intracellular calcium plays a major role in airway smooth muscle (ASM) contraction and relaxation.

Altered airway reactivity to bronchoconstrictors versus bronchodilators underlies diseases such as asthma and the septic lung. Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation and undergoes hypertrophy and hyperplasia, contributing to airway remodeling in asthma.

ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in chronic severe asthma, increases in ASM mass may render the airway Cited by: Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma.

This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease.

The Third Edition has undergone radical revision and.Background: Recent studies have suggested that eosinophils may have a direct effect on airway smooth muscle cells (ASMC), causing their proliferation in patients with asthma, but the precise mechanism of the interaction between these cells remains propose that changes in Wnt signaling activity and extracellular matrix (ECM) production may help explain these findings.